Title of article
Synthesis of Novel Functionalised Symmetric Bi-2(1H)-pyrazinones
Author/Authors
Dehaen، Wim نويسنده , , Borggraeve، Wim M. De نويسنده , , Appukkuttan، Prasad نويسنده , , Azzam، Rasha نويسنده , , Compernolle، Frans نويسنده , , Eycken، Erik Van der نويسنده , , Hoornaert، Georges نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-776
From page
777
To page
0
Abstract
A simple and convenient synthesis for functionalised bi-2(1H)-pyrazinones 9, 11a-h starting from 3,5-dichloro-2(1H)-pyrazinones 7, 10a-h is described. The pyrazinone is homo-coupled by means of a Suzuki-type reaction of an in situ generated boronate. The reactions were carried out under conventional heating as well as under microwave irradiation and dramatic improvements in the rates and yields have been observed under the latter conditions.
Keywords
bis-heterocycle , pyrazinone , Suzuki chemistry , bis(pinacolato)diboron
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110256
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