Title of article
Total synthesis of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK
Author/Authors
Satoru Tamura، نويسنده , , Shunsuke Doke، نويسنده , , Nobutoshi Murakami، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
8476
To page
8480
Abstract
The first total synthesis of peumusolide A (1) has been achieved by combination of regio- and stereo-selective aluminum-mediated hydroiodination to 2-yn-1-ol and enantioselective reduction of 4-en-1-yn-3-one with the chiral oxazaborolidine as the key reactions. This total synthesis has unequivocally established our proposed absolute structure of 1.
Keywords
Peumusolide A , Hydroiodination , asymmetric reduction , Total synthesis , MEK-export inhibitor
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102600
Link To Document