Title of article
An Unusual Intramolecular Acetal Alkylation
Author/Authors
Gao، Xiuchun نويسنده , , Seth، Punit P. نويسنده , , Bitok، John K. نويسنده , , Totah، Nancy I. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-818
From page
819
To page
0
Abstract
Upon treatment with Grignard reagents, suitably functionalized cis-fused bicyclic ketone acetals undergo intramolecular acetal alkylation to provide oxabicyclo[3.3.1]nonane derivatives. This transformation results in the formation of up to three stereogenic centers with high levels of stereoselectivity. Product distribution and stereochemistry vary with substrate substitution and the Grignard reagent utilized.
Keywords
annulation , Grignard reagents , Stereoselectivity , alkylation , acetals
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110267
Link To Document