Title of article
Reinvestigation on total synthesis of kaitocephalin and its isomers
Author/Authors
Shouyun Yu، نويسنده , , Shaolin Zhu، نويسنده , , Xianhua Pan، نويسنده , , Jiade Yang، نويسنده , , Dawei Ma، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
8
From page
1673
To page
1680
Abstract
Aldol reaction of 2,5-disubstituted pyrrolidine 3b with (R)-Garner aldehyde followed by Sharpless asymmetric dihydroxylation and other four reactions afforded mesylate 8a, which was introduced by an amide group via three ordinary transformations to provide amide 9a. Careful deprotection with AlCl3/Me2S and subsequent HPLC purification furnished kaitocephalin.
Keywords
Natural product , Asymmetric synthesis , Amino acid , Aldol reaction , Oxazolidine
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1102995
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