Organocatalytic enantioselective multicomponent cascade reaction: facile access to tetrahydropyridines with C3 all-carbon quaternary stereocenters

A novel organocatalytic asymmetric multicomponent cascade reaction for the synthesis of valuable tetrahydropyridines has been developed. The merit of this cascade process is highlighted by its high efficiency of producing five new bonds and an all-carbon quaternary stereocenter in one operation, which otherwise is a big challenge to access by traditional strategies.