Title of article
Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one
Author/Authors
Patrizia Diana، نويسنده , , Antonina Stagno، نويسنده , , Paola Barraja، نويسنده , , Alessandra Montalbano، نويسنده , , Anna Carbone، نويسنده , , Barbara Parrino، نويسنده , , Girolamo Cirrincione، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
3374
To page
3379
Abstract
Derivatives of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one were prepared in four steps starting from substituted benzonitriles bearing a functionalized amino group in the adjacent position. The unsubstituted- and the dimethoxy-pyrrolizinoindolones 5a and 5b exhibited modest activity against the HL-60(TB) human leukemia cell line, whereas the N-methylated dimethoxy-pyrrolizinoindolone 6b showed to be selective against MOLT-4 leukemia, A549/ATCC, HOP-92, and NCI-H460 non-small cell lung cancer, and CAKI-1 renal cancer cell lines.
Keywords
Tripentone , Antitumor activity , Antitubulin agents , 3-b]indol-4(5H)-one
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103191
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