Title of article
Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles
Author/Authors
Serghei Chercheja، نويسنده , , Juliet K. Simpson، نويسنده , , Hon Wai Lam، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
7
From page
3839
To page
3845
Abstract
A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide. These reactions proceed via the Thorpe–Ziegler cyclization of the dinitrile to form an intermediate β-cyanoenamine, which then undergoes annulation with the mononitrile in situ.
Keywords
4-Aminopyrimidine , Dinitrile , nitrile , Cyclization , Base catalysis
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103242
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