Title of article
Palladium-catalyzed, asymmetric Baeyer–Villiger oxidation of prochiral cyclobutanones with PHOX ligands
Author/Authors
Kimberly S. Petersen، نويسنده , , Brian M. Stoltz، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
4352
To page
4357
Abstract
Described in this report is a general method for the conversion of prochiral 3-substituted cyclobutanones to enantioenriched γ-lactones through a palladium-catalyzed Baeyer–Villiger oxidation using phosphinooxazoline ligands in up to 99% yield and 81% ee. Lactones of enantiopurity ≥93% could be obtained through a single recrystallization step. Importantly, 3,3-disubtituted cyclobutanones produced enantioenriched lactones containing a β-quaternary center.
Keywords
Phosphinooxazoline ligands , Baeyer–Villiger oxidation , Palladium , Asymmetric catalysis
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103309
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