In situ generation of palladium nanoparticles: ligand-free palladium catalyzed ultrafast Suzuki–Miyaura cross-coupling reaction in aqueous phase at room temperature

An ultrafast and highly efficient ligand-free Suzuki–Miyaura cross-coupling reaction between aryl bromides/iodides and arylboronic acids using palladium chloride as catalyst in PEG400/H2O in air at room temperature has been developed. TEM showed that palladium nanoparticles were generated in situ from PdCl2/PEG400/H2O without use of other reductants. The catalyst system can be recycled to reuse three times with good yields.