Title of article
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions
Author/Authors
Claudia Mugnaini، نويسنده , , Chiara Falciani، نويسنده , , Igor Maria De Rosa، نويسنده , , Antonella Brizzi، نويسنده , , Serena Pasquini، نويسنده , , Federico Corelli، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
8
From page
5776
To page
5783
Abstract
A practical and general synthesis of 1,3,6-trisubstituted quinolin-4(1H)-ones starting from 1-alkyl-6-bromo-3-iodoquinolin-4(1H)-one is described, based on regioselective sequential palladium-catalyzed cross-coupling reactions, namely Suzuki–Miyaura, Sonogashira and aminocarbonylation reactions, under microwave irradiation. Good substrate generality, ease of execution and practicability make this method exploitable for the generation of libraries of chemically diverse 4-quinolones.
Keywords
Heterogeneous catalysis , Homogeneous catalysis , Quinolin-4(1H)-ones , Palladium , Cross-coupling
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103495
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