Title of article
Total synthesis of pyripyropene A
Author/Authors
Atsuki Odani، نويسنده , , Kaoru Ishihara، نويسنده , , Masaki Ohtawa، نويسنده , , Hiroshi Tomoda، نويسنده , , Satoshi Omura، نويسنده , , Tohru Nagamitsu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
9
From page
8195
To page
8203
Abstract
The total synthesis of pyripyropene A, a potent ACAT2 inhibitor with high isozyme selectivity, was completed. Key features of the synthetic strategy include Ti(III)-mediated radical cyclization and Peterson olefination for the construction of the AB ring segment and stereoselective dihydro-γ-pyrone formation (C-ring). The total synthesis provided pyripyropene A in 5.3% overall yield over 17 steps.
Keywords
Pyripyropene A , Total synthesis , ACAT2 inhibitor
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103772
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