Title of article
Reaction of Tröger’s base analogues with Vilsmeier reagents
Author/Authors
Qasim M. Malik، نويسنده , , Andrew B. Mahon، نويسنده , , Donald C. Craig، نويسنده , , Andrew C. Try، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
8509
To page
8514
Abstract
As part of a program aimed at introducing functionality onto the Tröger’s base framework post-synthesis, we investigated the formylation reaction of Tröger’s base analogues with Vilsmeier reagents. We found that rather than the anticipated reaction at the aryl rings, these compounds react with Vilsmeier reagents to afford compounds with a modified strap, whereby the apical methylene group is replaced by a methylene strap bearing an N,N-disubstituted amine.
Keywords
X-ray , Vilsmeier , Tr?ger’s base , Chirality , Bridge-modification
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103812
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