Title of article
An efficient enantioselective synthesis of florfenicol via asymmetric aziridination
Author/Authors
Zhonghua Wang، نويسنده , , Feng Li، نويسنده , , Lei Zhao ، نويسنده , , Qiuqin Zhang، نويسنده , , Fener Chen، نويسنده , , Han-Chen Zheng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
9199
To page
9203
Abstract
An efficient enantioselective synthesis of florfenicol is accomplished in 44.7% overall yield from commercially available p-(methylsulfonyl)benzaldehyde. Key features of this synthesis are the asymmetric aziridination reaction mediated by the Wulff’s catalyst in situ derived from (R)-VANOL and diastereoselectively ring-opening of (2S,3S)-fluoroaziridine 13.
Keywords
Asymmetric aziridination , Florfenicol , Middleton fluorination , VANOL , Aziridine
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103887
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