Title of article
Synthesis of (3RS,3aSR,8aSR)-3-phenyloctahydrocyclohepta[b]pyrrol-4(1H)-one via the aza-Cope–Mannich rearrangement
Author/Authors
Dmitry S. Belov، نويسنده , , Evgeny R. Lukyanenko، نويسنده , , Alexander V. Kurkin، نويسنده , , Marina A. Yurovskaya، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
9214
To page
9218
Abstract
A convenient and scalable method for the preparation of (3RS,3aSR,8aSR)-phenyloctahydrocyclohepta[b]pyrrol-4(1H)-one based on the aza-Cope–Mannich rearrangement is described. This approach allows us to synthesize the target compound in nine steps in a high overall yield (42%) with complete stereocontrol and up to 100 g scale.
Keywords
Multigram preparation , Natural-like compounds , Aza-Cope–Mannich , Allyl protective group
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103889
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