Title of article
Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure
Author/Authors
Stephen G. Davies، نويسنده , , Ai M. Fletcher، نويسنده , , Deri G. Hughes، نويسنده , , James A. Lee، نويسنده , , Paul D. Price، نويسنده , , Paul M. Roberts، نويسنده , , Angela J. Russell، نويسنده , , Andrew D. Smith، نويسنده , , James E. Thomson، نويسنده , , Oliver M.H. Williams، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
18
From page
9975
To page
9992
Abstract
The conjugate addition of an enantiopure lithium amide to a ζ-hydroxy-α,β-unsaturated ester followed by a one-pot ring-closure/N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts), and (R,R)-1-(hydroxymethyl)octahydroindolizine (the bicyclic fragment of stellettamides A–C).
Keywords
lithium amide , Asymmetric synthesis , ?-Coniceine , Coniine , piperidines
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103973
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