Title of article
Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3
Author/Authors
Ade Arsianti، نويسنده , , Hiroki Tanimoto، نويسنده , , Tsumoru Morimoto، نويسنده , , Anton Bahtiar، نويسنده , , Tatsuo Takeya، نويسنده , , Kiyomi Kakiuchi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
8
From page
2884
To page
2891
Abstract
A novel polyhydroxylated 18-membered analogue of antimycin A3 was synthesized. Our synthesis commenced with Boc-l-threonine and was achieved by way of one-pot homocoupling/ring-closing olefin metathesis reaction cascade and Sharpless asymmetric dihydroxylation. The analogue exhibited a greater anticancer activity against HeLa cells, breast MDA-MB-231 cells, and prostate PC-3 cells compared to the original antimycin A3.
Keywords
Synthesis , Anticancer , Polyhydroxylated 18-membered ring , Antimycin A3 , Analogue
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104346
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