Title of article
The enzymatic asymmetric aldol reaction using acidic protease from Aspergillus usamii
Author/Authors
Bang-Hua Xie، نويسنده , , Wei Li، نويسنده , , Yan Liu، نويسنده , , Hai-Hong Li، نويسنده , , Zhi Guan، نويسنده , , Yan-Hong He، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
3160
To page
3164
Abstract
AUAP (acidic protease from Aspergillus usamii) could catalyze the direct aldol reactions between aromatic aldehydes and cyclic ketones in acetonitrile (MeCN) in the presence of water. The enantioselectivities of up to 88% ee and diastereoselectivities of up to 97:3 (anti/syn) were achieved. This new activity of protease expands the application of the biocatalyst and provides a novel example of enzymatic promiscuity.
Keywords
Biocatalytic promiscuity , Acidic protease , Enantioselectivity , Aldol reaction
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104377
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