Title of article
Utilization of DmbNHNH2 in the synthesis of amino-substituted 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenols
Author/Authors
Eva Schütznerov?، نويسنده , , Igor Popa، نويسنده , , Vladim?r Kry?tof، نويسنده , , Hiroyuki Koshino، نويسنده , , Zden?k Tr?vn??ek، نويسنده , , Pavel Hradil، نويسنده , , Petr Canka?، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
7
From page
3996
To page
4002
Abstract
(2,4-Dimethoxybenzyl)hydrazine (DmbNHNH2) was utilized in the synthesis of Dmb-protected 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenols. This unambiguous protection of the pyrazole endocyclic nitrogen atom enabled the preparation of amino-substituted 4-((3,5-diamino-1H-pyrazol-4yl)diazenyl)phenols that were inaccessible through direct substitution. The Boc group could be selectively cleaved in the presence of the Dmb group.
Keywords
Nitrogen heterocycles , Regioselective acylation , CDK inhibitors , Dmb-protecting group , (2 , 4-Dimethoxybenzyl)hydrazine
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104485
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