Title of article
Asymmetric aza-Friedel–Crafts reaction of indoles induced by O-pivaloylated d-galactosylamine as the chiral auxiliary
Author/Authors
Haohao Yang، نويسنده , , Bing Cui، نويسنده , , Guiping Wu، نويسنده , , Zhiwei Miao، نويسنده , , Ruyu Chen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
8
From page
4830
To page
4837
Abstract
The diastereoselective formation of β-N-glycosidically linked 3-indolyl methanamine derivatives 5 has been achieved with high yield via an aza-Friedel–Crafts reaction. The reaction was performed by using O-pivaloylated galactosylamine 1 as a chiral template and SnCl4 combining TBAI as catalyst in DCM at −50 °C.
Keywords
Aza-Friedel–Crafts reaction , Asymmetric synthesis , Lewis acid catalyzed , Carbohydrate auxiliaries , Indole
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104579
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