Title of article
A new and facile access to the 2-(indol-3-yl)-3-nitriloquinolines based on Friedländer annulations
Author/Authors
Morteza Shiri، نويسنده , , Mohammad Ali Zolfigol، نويسنده , , Mahtab Pirveysian، نويسنده , , Roya Ayazi-Nasrabadi، نويسنده , , Hendrik G. Kruger، نويسنده , , Tricia Naicker، نويسنده , , Iraj Mohammadpoor-Baltork، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
6059
To page
6064
Abstract
Preparation of 2-(indol-3-yl)-3-nitriloquinolines via Friedländer quinoline synthesis using 3-cyanoacetylindoles possessing an α-methylene group and ortho-amino arylketones have been described. This reaction took place in PEG-400 as a green solvent and it is catalyzed with polyphosphoric acid (PPA) to give novel types of quinolines containing both indoles and cyano functions in one step under thermal and microwave conditions.
Keywords
Quinolines , Indoles , Friedl?nder quinoline synthesis , Ethylene glycol
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104728
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