Title of article
Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates
Author/Authors
George E. Magoulas، نويسنده , , Thomas Garnelis، نويسنده , , Constantinos M. Athanassopoulos، نويسنده , , Dionissios Papaioannou، نويسنده , , George Mattheolabakis، نويسنده , , Konstantinos Avgoustakis، نويسنده , , Dimitra Hadjipavlou-Litina، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
9
From page
7041
To page
7049
Abstract
(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C60, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.
Keywords
Fullerenes , Polyamines , Conjugates , Anti-inflammatory activity , Lipoxygenase inhibitors
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104835
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