Title of article
A one-pot selective synthesis of N-Boc protected secondary amines: tandem direct reductive amination/N-Boc protection
Author/Authors
Raghupathi Neelarapu، نويسنده , , Pavel A. Petukhov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
7
From page
7056
To page
7062
Abstract
A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)2O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization.
Keywords
Direct reductive amination , Secondary amines , N-Boc protection , Tandem reaction , Sodium triacetoxyborohydride
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104837
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