Title of article
A new and efficient synthesis of 1,3,4-oxadiazole derivatives using TBTU
Author/Authors
Shokoofeh Maghari، نويسنده , , Sorour Ramezanpour، نويسنده , , Fatemeh Darvish، نويسنده , , Saeed Balalaie، نويسنده , , Frank Rominger، نويسنده , , Hamid Reza Bijanzadeh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
2075
To page
2080
Abstract
An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from isothiocyanates and hydrazides through cyclodesulfurization in the presence of (O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate) TBTU as an uronium coupling reagent has been developed. The present methodology offers several advantages, such as simple and easy work-up procedures, mild reaction conditions and it is environmentally benign.
Keywords
1 , 3 , 4-oxadiazole , TBTU , Isothiocyanate , Hydrazides , coupling reagent
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105529
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