Title of article
Total synthesis of α-conotoxin MII using a soluble-tag-assisted method
Author/Authors
Shingo Kitada، نويسنده , , Shuji Fujita، نويسنده , , Yohei Okada، نويسنده , , Shokaku Kim، نويسنده , , Kazuhiro Chiba، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
2555
To page
2559
Abstract
Oxidative disulfide bond formations have been applied to soluble-tag-assisted method successfully to realize the total synthesis of α-conotoxin MII (4) that comprises 16 amino acid residues and possesses 2 disulfide bonds. Orthogonal peptide folding using DEAD and iodine oxidations in combination with Mmt and Acm groups for the side chain protection of cysteines could be carried out with no peptide aggregation.
Keywords
?-Conotoxin MII , Liquid-phase peptide synthesis , Hydrophobic benzyl amine , Soluble tag , disulfide bond
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105586
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