Title of article
A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo[2,1-f][1,2,4] triazin-4(3H)-ones
Author/Authors
Yanhong Chen، نويسنده , , Haoyue Xiang، نويسنده , , Cun Tan، نويسنده , , Yuyuan Xie، نويسنده , , Chunhao Yang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
2714
To page
2719
Abstract
An efficient tandem method for the annulation of 1-amino-1H-pyrrole-2-amides with various substituted benzaldehydes, heteroaryl aldehydes, alkyl aldehydes or even acetals, promoted by cupric chloride, to synthesize 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones is reported. This approach provides a useful method for constructing the privileged structure in medicinal chemistry. Electron-donating groups on both partners could accelerate the reaction.
Keywords
Tandem annulation , Cupric chloride , Privileged structure , 2 , 4]triazin-4(3H)-ones , 1-Amino-1H-pyrrole-2-amides
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105606
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