Title of article
Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues
Author/Authors
Tie-Wen Mei، نويسنده , , Yu Luo، نويسنده , , Xiang-Jun Feng، نويسنده , , Wei Lu، نويسنده , , Bo Yang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
2927
To page
2932
Abstract
A concise synthesis of Fingolimod (FTY720) and its analogues was described. The key step involved Suzuki coupling of arylboronate 11 with different bromides. In addition, the newly synthesized Fingolimod analogues (5a–i and 6a–c) were evaluated for their in vitro cytotoxicity against SMCC-7721 and HL-60 cell lines. The preliminary SAR was discussed.
Keywords
concise synthesis , Suzuki coupling , Key step , Cytotoxicity
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105628
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