Title of article
Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives
Author/Authors
Massaba Keita، نويسنده , , Rocco De Bona، نويسنده , , Mickaël Dos Santos، نويسنده , , Olivier Lequin، نويسنده , , Sandrine Ongeri، نويسنده , , Thierry Milcent، نويسنده , , Benoît Crousse، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
8
From page
3308
To page
3315
Abstract
Novel regioisomers of trifluoromethylated cyclopropanes have been synthesized by Michael addition and nucleophilic cyclization process. The reaction was carried out with the trifluoromethylcrotonate 6 and nucleophilic reagents. Fluorinated cyclopropanes were obtained with good to excellent diastereoselectivities. Furthermore, interesting constrained building blocks have emerged from this methodology.
Keywords
Cyclopropanes , Michael addition , constrained amino acids , Fluorine , peptidomimetics
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105673
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