Title of article
One-pot synthesis of 5-oxopyrrolidine-2-carboxamides via a tandem Ugi 4CC/SN cyclization starting from Baylis–Hillman bromides
Author/Authors
Xiao-Hua Zeng، نويسنده , , Hongmei Wang، نويسنده , , Lei Wu، نويسنده , , Ming-Wu Ding، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
3823
To page
3828
Abstract
A one-pot base-mediated synthesis of 5-oxopyrrolidine-2-carboxamides was developed. The reaction of Baylis–Hillman bromides 1, primary amines 2, isocyanides 3 and arylglyoxals 4 produced the 5-oxopyrrolidine-2-carboxamides 6 in good yields via a tandem Ugi condensation and intramolecular substitution at room temperature in the presence of Cs2CO3.
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105731
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