Title of article
Novel One-Pot Cycloisomerization-Knoevenagel Condensation Sequences with Yne Allyl Alcohols
Author/Authors
Muller، Thomas J. J. نويسنده , , Kressierer، Christoph J. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1720
From page
1721
To page
0
Abstract
The sequential Pd-catalyzed cycloisomerization-Knoevenagel condensation of alkyne allyl alcohols 1 and CH-acidic compounds, such as acetylacetone (2a), dimethyl malonate (2b) or malononitrile (2c), furnishes the 2,6-dienes 3 in moderate to good yield. Upon reacting 1,3-cyclohexadione (4a) or dimedone (4b) under the same reaction conditions pseudo-threecomponent products 5 are formed as a consequence of a consecutive cycloisomerization-condensation-addition sequence in 57-88% yield.
Keywords
ene reactions , additions , Alkynes , condensations , catalysis
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110589
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