Title of article
Preparation of chiral key intermediates of morpholine based neurokinin receptor antagonists by asymmetric allylic alkylation
Author/Authors
Jérôme Keldenich، نويسنده , , Audrey Denicourt-Nowicki، نويسنده , , Christophe Michon، نويسنده , , Francine Agbossou-Niedercorn، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
6424
To page
6430
Abstract
The preparation of optically active morpholine-2-aryl-2-allyl derivative from morpholine-2-aryl-3-ones is reported. The optically active tetrasubstituted stereocenter is introduced during a palladium promoted asymmetric allylic alkylation. The resulting compounds are useful intermediates in the synthesis and development of potent NK antagonists.
Keywords
Alkylation , Palladium , Asymmetric catalysis , Heterocycle
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106044
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