Synthesis and antiplasmodial evaluation of cyclopropyl analogs of the G-factor bicyclic peroxide

New bicyclic peroxyketal comprising cyclopropyl moieties, analogs of the G3-factor, have been synthesized and evaluated against Plasmodium falciparum. They exhibit modest antimalarial activities. In order to investigate their mode of action, Fe(II) induced reduction was managed allowing us to establish mechanisms involved on the basis of the structure of the final products. Self-quenching and polymerization seem to be the major degradation ways.