Title of article
Asymmetric Michael Addition of Arylthiols to (alpha),(beta)-Unsaturated Carbonyl Compounds Catalyzed by Bifunctional Organocatalysts
Author/Authors
Jiang، Yao-Lin نويسنده , , Liu، Min نويسنده , , Li، Bang-Jing نويسنده , , Chen، Ying-Chun نويسنده , , Ding، Li-Sheng نويسنده , , Wu، Yong نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-602
From page
603
To page
0
Abstract
Bifunctional chiral organocatalysts comprising thiourea and tertiary amine groups were synthesized. They act as efficient catalysts for asymmetric Michael addition of arylthiols to (alpha),(beta)-unsaturated carbonyl compounds. Enantioselectivity up to 85% has been achieved. Asymmetric (alpha)-protonation reaction (up to 60% ee) can be obtained in the presence of the bifunctional catalyst.
Keywords
hydrogen bonding , asymmetric Michael addition , asymmetric protonation , Thiourea , bifunctional organocatalyst
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110611
Link To Document