Title of article
Biomimetic synthesis of an antitumour indole sesquiterpene alkaloid, 12-epi-ent-pentacyclindole
Author/Authors
Isidro S. Marcos، نويسنده , , Rosalina F. Moro، نويسنده , , Isabel Costales، نويسنده , , Pilar Basabe، نويسنده , , David Diez، نويسنده , , Faustino Mollinedo، نويسنده , , Julio G. Urones، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
7285
To page
7289
Abstract
Biomimetic synthesis of 12-epi-ent-pentacyclindole 7, using as key step the cyclization of 12-epi-ent-polyalthenol acetate has been carried out. This way, the structure and absolute configuration of the natural product pentacyclindole 1 has been confirmed. The synthesized indole sesquiterpenes 7, 11 and 12 show cellular proliferation inhibition of a number of human leukaemic and solid tumour cell lines.
Keywords
Pentacyclindole , Polyalthenol , Antitumour , ent-halimic acid , Indole sesquiterpenes
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106144
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