Title of article
Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding
Author/Authors
Nathan T. Ross، نويسنده , , Rashid Deane، نويسنده , , Sheldon Perry، نويسنده , , Benjamin L. Miller، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
7653
To page
7658
Abstract
The Receptor for Advanced Glycation Endproducts (‘RAGE’) mediates transport of amyloid-β peptide (Aβ) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimerʹs disease. We describe structure–activity relationships for inhibition of RAGE-Aβ binding, derived from the analysis of a library of tertiary amides.
Keywords
Focused library , Alzheimerיs disease , Receptor for advanced glycation endproducts , Amyloid beta peptide
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106185
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