Title of article
Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils
Author/Authors
Mehdi Bakavoli، نويسنده , , Hossein Eshghi، نويسنده , , Ali Shiri، نويسنده , , Toktam Afrough، نويسنده , , Javad Tajabadi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
8470
To page
8476
Abstract
The sodium salts of the conjugated bases of uracils undergo highly chemoselective O4-monoalkylation when treated with various alkyl halides in dry DMF, while the use of methyl iodide results in N1+N3-dimethylation. Theoretical evaluations of the chemo- and regioselectivity along with X-ray crystallographic data are presented.
Keywords
6-Methyl uracil , HMDS , O-alkylation , GIAO 13C NMR
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106282
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