Title of article
A novel asymmetric organocatalytic Michael–aldol–dehydration domino reaction for the construction of spirocyclic benzofuranones
Author/Authors
Liang-Wen Qi، نويسنده , , Liang-liang Wang، نويسنده , , Lin Peng، نويسنده , , Li-Na Jia، نويسنده , , Fang Tian، نويسنده , , Xiao-Ying Xu، نويسنده , , Li-Xin Wang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
9303
To page
9308
Abstract
Organocatalytic Michael–aldol–dehydration domino reaction of 3-(1-hydroxyethylidene)benzofuran-2(3H)-ones and enones catalyzed by Cinchona-based primary amine has been developed. The desired chiral spirocyclic benzofuranones were obtained in excellent stereoselectivities (dr>20:1 and up to 96% ee) and moderate to excellent yields (up to 98%).
Keywords
Organocatalysis , Asymmetric catalysis , domino reaction , Benzofuranone , Spirocyclic compound
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106383
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