Title of article
Convenient synthesis of pyrrolo[3,4-g]indazole
Author/Authors
Virginia Span?، نويسنده , , Alessandra Montalbano، نويسنده , , Anna Carbone، نويسنده , , Barbara Parrino، نويسنده , , Patrizia Diana، نويسنده , , Girolamo Cirrincione، نويسنده , , Paola Barraja، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
9
From page
9839
To page
9847
Abstract
The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of the pyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones key intermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQ of the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated at the National Cancer Institute of Bethesda and some derivatives showed modest activity.
Keywords
antiproliferative activity , Regioselectivity , 4-g]indazole , Hydroxymethyleneketones
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106447
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