Title of article
Synthesis of phenylalkyl-substituted polyhydroxypiperidines as potent inhibitors for α-l-fucosidase
Author/Authors
Tomoki Saka، نويسنده , , Toru Okaki، نويسنده , , Shohei Ifuku، نويسنده , , Yukiko Yamashita، نويسنده , , Kasumi Sato، نويسنده , , Shota Miyawaki، نويسنده , , Akiko Kamori، نويسنده , , Atsushi Kato، نويسنده , , Isao Adachi، نويسنده , , Yasuhiro Tezuka، نويسنده , , Peter G. Kiria، نويسنده , , Osamu Onomura، نويسنده , , Daishiro Minato، نويسنده , , Kenji Sugimoto، نويسنده , , Yuji Matsuya، نويسنده , , Naoki Toyooka، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
9
From page
10653
To page
10661
Abstract
Synthesis and inhibitory activities against α-l-fucosidase of phenylalkyl-substituted polyhydroxypiperidines have been described. Among the newly synthesized compounds, 2,4,6-trichloro derivative (16q) showed very high inhibitory activity against α-l-fucosidase with IC50 value of 0.005 μM, and Ki values of 0.0011 μM, respectively.
Keywords
Iminosugar , l-Fucose , C-1 phenylalkyl-substituted polyhydroxypiperidine , ?-l-fucosidase
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106547
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