Title of article
Synthesis of a bicyclic double-headed nucleoside
Author/Authors
Surender Kumar Pal، نويسنده , , Signe Inglev Steffansen، نويسنده , , Nanna Alb?k، نويسنده , , Poul Nielsen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
7
From page
583
To page
589
Abstract
An attempt of preparing a carbocyclic LNA-analogue using different RCM-methods failed. However, a compound with a hemiacetal linker between the C2′ and the C4′-positions was isolated and found to be a suitable substrate for making a conformationally restricted double-headed nucleoside. This contains two uracil nucleobases organized on a bicyclic skeleton and is locked in an N-type conformation.
Keywords
Double-headed nucleosides , Vorbrüggen coupling , Ring-closing metathesis , Bicyclic nucleosides
Journal title
Tetrahedron
Serial Year
2014
Journal title
Tetrahedron
Record number
1106679
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