Title of article
Acid-Mediated Highly Regioselective Oxidation of Substituted Furans: A Simple and Direct Entry to Substituted Butenolides
Author/Authors
Cenal، Juan P. نويسنده , , Carreras، Carlos R. نويسنده , , Tonn، Carlos E. نويسنده , , Padron، Juan I. نويسنده , , Ramirez، Miguel A. نويسنده , , Diaz، David D. نويسنده , , Garcia-Tellado، Fernando نويسنده , , Martin، Victor S. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1574
From page
1575
To page
0
Abstract
The scope and limitations of an expeditious synthesis of substituted butenolides from 3-substituted or 3,4-disubstituted furans is described. The entire process embodies a controlled oxidation of the furan core to a 2,5dialkoxy-dihydrofuran intermediate and a regioselective acid-catalyzed hydrolysis to the butenolide derivative. 3-Substituted furans yield exclusively 2-substituted butenolides. Calculations studies provide substantiation of a proposed mechanism.
Keywords
substituted butenolides , Furans , Oxidation
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110697
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