Amphiphilic Trithiols RC(CH2SH)3

We report on the synthesis of the amphiphilic molecules 1,1,1-tris(mercaptomethyl)undecane and 1,1,1-tris(mercaptomethyl) dec-9-ene starting from the corresponding tris(hydroxymethyl) compounds. In addition we describe the synthesis of an amphiphilic phosphite ligand possessing only one alkyl chain. These compounds are potential substrates for the monolayer protection of 2D surfaces and nanoparticles.