Title of article
Chemical composition and anxiolytic evaluation of Achillea Wilhelmsii C. Koch essential oil in rat
Author/Authors
Majnooni، M.B. نويسنده Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. , , Mohammadi-Farani، A. نويسنده Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. , , Gholivand ، MB نويسنده Razi University , , Nikbakht، M.R. نويسنده Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. , , Bahrami، G.R. نويسنده Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. ,
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2013
Pages
7
From page
269
To page
275
Abstract
Herbal based remedies are used worldwide to treat psychiatric disorders. The aim of this study was to analyse the essential oil composition of Achillea Wilhemsii C. Koch (Asteraceae) and to evaluate its anxiolytic effects in the elevated plus maze (EPM) model of anxiety in rat. Gas chromatography/mass spectrometry (GC/MS) analysis of the essential oil showed that the main compounds of the oil were p-ocimen (23%), 1, 8-cineole (20.8%) and carvone (19.13%). The EPM results showed that 1 mg/kg (i.p.) of the oil significantly (P < 0.05) increased the percentage of the time spent and the number of entries in the open arms of the maze while it did not change the total number of entries in the maze arms. These effects were not reversed with 2 mg/kg flumazenil and 5 mg/kg naloxone. We concluded that a minimum dose of 1 mg/kg of the oil has anxiolytic effects which are not probably mediated through GABA and opioid receptors.
Journal title
Research in Pharmaceutical Sciences
Serial Year
2013
Journal title
Research in Pharmaceutical Sciences
Record number
1109273
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