Title of article
Synthesis of THIQ Derivatives as Potential Boron Neutron Capture Therapy Agents: N-Functionalized o-Carboranylmethyl Benzopiperidines
Author/Authors
Ko، Jaejung نويسنده , , Kang، Sang Ook نويسنده , , Lee، Jong-Dae نويسنده , , Lee، Chai-Ho نويسنده , , Oh، Jung Mee نويسنده , , Nakamura، Hiroyukiki نويسنده ,
Pages
-274
From page
275
To page
0
Abstract
A method for synthesizing o-carborane substituted tetrahydroisoquinolines containing a polar functional group such as sulfonic or phosphoric acid on the nitrogen atom of the piperidine ring, starting from N-(2-arylethyl)sulfamic acid or 2arylethylamidophosphate, is described. In vitro studies showed that the desired compounds 7a and 10b accumulate to high levels in B-16 melanoma cells despite low cytotoxicity.
Keywords
BNCT , o-carborane , tetrahydroisoquinoline , 2-arylethylamine , iminium ion
Journal title
Astroparticle Physics
Record number
111016
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