Title of article
An Efficient Asymmetric Synthesis of Cascarillic Acid
Author/Authors
Bull، Steven D. نويسنده , , Cheeseman، Matt نويسنده ,
Pages
-1118
From page
1119
To page
0
Abstract
An efficient six-step asymmetric synthesis of the cyclopropane containing natural product cascarillic acid in 41% overall yield is described. The key synthetic steps involve the use of a temporary stereogenic hydroxyl group to control the facial selectivity of a directed cyclopropanation reaction and its subsequent removal via a retro-aldol reaction.
Keywords
cascarillic acid , retro-aldol , temporary stereocentre , cyclopropane , aldol
Journal title
Astroparticle Physics
Record number
111066
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