Application of nanofiltration process in 5′-GMP production Original Research Article

In this study, an NF membrane named S-372 (200 MWCO and the negative charge) was successfully applied in 5′-GMP production. With NF process, 5′-GMP was concentrated from 20.9 g·L−1 to 130.6 g·L−1 and NaCl was desalted from 19.7 g·L−1 to 1.00 g·L−1. The pure water flux could be completely recovered by the alkaline detergent solution with pH 9.0. These results proved that NF process with S-372 could replace vacuum concentration and ethanol crystallization in the conventional process, having advantages of low energy consumption and being environment friendly.