Phase synchronization and coherence resonance of stochastic calcium oscillations in coupled hepatocytes Original Research Article

The frequency of free cytosolic calcium concentration ([Ca2+]) oscillations elicited by a given agonist concentration differs between individual hepatocytes. However, in multicellular systems of rat hepatocytes and even in the intact liver, [Ca2+] oscillations are synchronized and highly coordinated. In this paper, we have investigated theoretically the effects of gap junction permeable to calcium and of the total Ca2+ channel number located on endoplasmic reticulum on intercellular synchronization. Figures of ratio between mean oscillating frequency of coupled cells describe visually the process of phase-locking. By virtue of a set of phase analysis, we can observe a gradual transition from synchronous behavior to nonsynchronous behavior. Furthermore, a signal-to-noise ratio in two dimensional parameter space (coupling strength-total Ca2+ channel number) has suggested that, coherence resonance will occur for appropriate noise and coupling.