Title of article
Ligand-induced formation of Hoogsteen-paired parallel DNA Original Research Article
Author/Authors
Christophe Escudé، نويسنده , , Shahla Mohammadi، نويسنده , , Jian-Sheng Sun، نويسنده , , Chi Hung Nguyen، نويسنده , , Emile Bisagni، نويسنده , , Jean Liquier، نويسنده , , Eliane Taillandier، نويسنده , , Thérèse Garestier، نويسنده , , Claude Hélène، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 1996
Pages
9
From page
57
To page
65
Abstract
zIntroduction: Based on molecular modeling studies, a model has been proposed for intercalation of triple-helixspecific ligands (benzopyridoindole (BPI) derivatives) into triple helices, in which the intercalating compounds interact mainly with the Hoogsteen-paired strands of the triple helix. We set out to test this model experimentally using DNA duplexes capable of forming parallel Hoogsteen base-paired structures.
Results: We have investigated the possible formation of a parallel DNA structure involving Hoogsteen hydrogen bonds b
Keywords
* parallel DNA , * triple helix , * Hoogsteen , * intercalation
Journal title
Chemistry and Biology
Serial Year
1996
Journal title
Chemistry and Biology
Record number
1157761
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