Short strong hydrogen bonds: can they explain enzymic catalysis? Review Article

It has been proposed that some remarkable enzymic catalytic effects can be explained by the existence of unusually strong hydrogen bonds within the enzymeʹs active site. Although such hydrogen bonds may be short, and may have unusual properties, there is no evidence that unusually strong hydrogen bonds exist in solution or in enzyme active sites. Thus there is no basis for invoking strong hydrogen bonds to explain enzymic rate enhancements.