• Title of article

    Niemann-Pick NPC1: Sterols to the Rescue and Beyond

  • Author/Authors

    Tip W. Loo، نويسنده , , David M. Clarke، نويسنده ,

  • Issue Information
    ماهنامه با شماره پیاپی سال 2013
  • Pages
    2
  • From page
    297
  • To page
    298
  • Abstract
    In Niemann-Pick type C disease, the most prevalent I1061T mutation inhibits folding and trafficking of the NPC1 protein to the endosomes/lysosomes. In this issue of Chemistry & Biology, Ohgane and colleagues used pharmacological chaperones to repair the defect and identify a second sterol-binding site.
  • Journal title
    Chemistry and Biology
  • Serial Year
    2013
  • Journal title
    Chemistry and Biology
  • Record number

    1160401

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1160401