Thermodynamic studies on the effects of cisplatin or its analog complexes on actin polymerization

The effects of cisplatin or its analog complexes on actin polymerization have been studied by the microcalorimetric and viscosity methods at the temperature of 310.15 K. The thermodynamic parameters and the power–time curves of actin polymerization in the presence of cisplatin or its analog complexes (cis-DBDP, cis-DIDP, cis-DADP) are measured. The results show that there are different interaction mechanisms between actin and cisplatin or its analog complexes. The relative viscosity of actin polymer decreases in the presence of cisplatin or its analogs, and also shows Pt concentration dependence. It indicates that these compounds affect actin polymerization. It has been discussed from the experimental results that the presence of cisplatin or its analog complexes cause different polymerization mechanism of actin.